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Synthesis of Cu-64(II)-Bis(dithiocarbamatebisphosphonate) and Its Conjugation with Superparamagnetic Iron Oxide Nanoparticles: In Vivo Evaluation as Dual-Modality PET-MRI Agent

This interdisciplinary work describes both novel chemistry supporting clinical applications of newly available PET/MRI scanners, and demonstrates potential of combined modalities for lymphatic imaging in mice. It combines PET (high sensitivity) and MRI (high resolution) in one easily-radiolabelled particle, introducing the first bisphosphonate-dithiocarbamate conjugates for linking radiolabel (Cu-64) and MR-contrast (superparamagnetic iron oxide, SPIOs). The novel bisphosphonate conjugation led to further papers describing its use linking Tc-99m (allowing SPECT imaging) and polyethylene glycol (controlling blood half-life ) to SPIOs. A clinical trial evaluating the Tc-99m-nanoparticles for sentinel node detection in cancer surgery, using SPECT, MRI and magnetometry, has begun.