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The estimation of patient-specific cardiac diastolic functions from clinical measurements

This paper provides a unique way of quantifying the fundamental mechanism underpinning diastolic heart failure: the inability of cardiac muscle to relax. Specifically, this novel method decouples the estimation of myocardial stiffness from the estimation of diastolic residual active tension, using clinical MRI and pressure recordings. Results from the application of the method show residual active tension appears to be a highly promising candidate to delineate healthy and pathological data sets demonstrating an important metric for characterizing a common human disease. It is published in the leading medical imaging journal.