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Susceptibility gradient mapping (SGM) : A new postprocessing method for positive contrast generation applied to superparamagnetic iron oxide particle (SPIO)-labeled cells

This novel technique allows calculation of the spatial distribution of the susceptibility gradient using the phase information of MR images only. The technique can detect and quantify Iron Oxide contrast agents, which usually results in a negative contrast in the MR images. The advantage of this positive contrast technique has been validated in a comparison study (Varma, MAGMA 2009). A high-resolution version of the technique has been used for detection of interventional devices (Varma, Magn Reson Med. 2011), detection of labeled dendritic cells (Tavare, PlosOne 2011) and quantification of iron-oxide agent uptake in atherosclerotic plaque (Makowski, Circ Cardiovasc Imaging. 2011).