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Acute exacerbations of chronic obstructive pulmonary disease: Identification of biologic clusters and their biomarkers

Bafadhel was the Principal Investigator in this study and was responsible for study design, volunteer recruitment, sample collection, study analysis and writing of the manuscript. Barer took the central role in developing, organising and interpreting the bacteriological analyses. Five, previously unpublished quantitative PCRs were developed and validated for the study and were applied to over 1000 samples under his immediate supervision. He was directly involved in all the discussions leading to the paper and in both drafting and editing the paper.

182 exacerbation events were captured in 86 patients by prospective clinical monitoring and sampling sputum and blood from 145 patients at 3 monthly intervals when stable. Exacerbations were sampled at onset, 2, and 6 weeks. Over 100 data points were acquired at each visit and approximately 20,000 data points contributed to the final manuscript. Bafadhel coordinated the study, recruited patients, led the clinical phenotyping and was central to the analysis of the data and drafting of the manuscript.

Barer directly supervised all bacteriological analyses (over 1000 in number).