Output details

A replicated association between polymorphisms near TNFα and risk for adverse reactions to radiotherapy

The author made a substantial contribution to the conception and design of the study, to the organisation of the conduct of the study and to carrying out the study (including the acquisition of study data) and to the analysis and interpretation of study data. The author helped to draft the output and critiqued the output for important intellectual content.

Symonds was the Principal Investigator of the project and responsible for patient recruitment, scoring late radiation effects and recording other clinical data. Talbot was responsible for the laboratory work, data analysis and co-ordination with external collaborators. Both Symonds and Talbot contributed equally to manuscript writing and reviewing.

This paper was the culmination of four years work; two years collecting information and blood samples from 660 women treated by radiotherapy for breast cancer, and two years of typing genetic polymorphisms and carrying out data analysis. Work was carried out by multiple laboratory and clinical staff. Prof Symonds was clinical lead and in charge of cohort collection, Dr Talbot was scientific lead in charge of laboratory work and statistical analysis. The paper also includes data from key collaborators who provided replication cohorts. The paper is truly joint between clinicians and scientists, with neither being the principal investigator.