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15 - General Engineering

University of Oxford

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Article title

Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue

Type

D - Journal article

DOI

10.1073/pnas.1300136110

Title of journal

Proceedings of the National Academy of Sciences

Article number

Volume number

110

Issue number

First page of article

11982

ISSN of journal

0027-8424

Year of publication

2013

URL

Number of additional authors

Additional information

The paper summarizes an interdisciplinary multi-year development of a novel multiplexing method that allows for the imaging of 50 or more protein targets in paraffin embedded tissue sections. Dr Rittscher led the image analysis work necessary for preprocessing, registration and the computation of the subcellular tissue map. Based on this work Dr Rittscher has been invited to the HHMI Janelia Farms Research Campus Conference: What Can Computer Vision Do for Neuroscience and Vice Versa? (2008, 2010). The team conducted preclinical studies with pharmaceutical partners including Eli Lilly and Company The developed process is currently being commercialized by GE Healthcare.

Interdisciplinary

Cross-referral requested

Research group

E - Biomedical Engineering

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract