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13 - Electrical and Electronic Engineering, Metallurgy and Materials

Queen Mary University of London : B - Materials

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Output 39 of 93 in the submission

Article title

High-affinity glycopolymer binding to human DC-SIGN and disruption of DC-SIGN interactions with HIV envelope glycoprotein.

Type

D - Journal article

DOI

10.1021/ja1056714

Title of journal

J Am Chem Soc

Article number

Volume number

132

Issue number

First page of article

15130

ISSN of journal

1520-5126

Year of publication

2010

URL

Number of additional authors

Additional information

We have demonstrated for the first time the interaction between dendritic cell lectin (DC-SIGN) and synthetic glycopolymers using surface plasmon resonance spectroscopy. Mannosylated glycopolymers can be used to inhibit HIV glycoprotein binding to DC-SIGN, which block one of the main pathways of HIV entry into immune system. This approach has been extended to other glycopolymer architectures and our current results are very exciting because certain architectures can provide higher affinity than natural glycoprotein. This approach can be used to reduce the impact of infectious diseases.

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract