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Inferring Biological Mechanisms from Spatial Analysis: Prediction of a Local Inhibitor in the Ovary

The multidisciplinary work, in collaboration with Imperial College London (Prof. Steve Franks, s.franks@imperial.ac.uk), proposes a novel approach for the spatial analysis of biological cells to identify sources of regulatory molecules. The method quantifies the relative spatial positions of biological structures in histological tissue sections and narrows the field for candidate growth factors or antagonists. This approach has wide applicability within diverse branches of developmental and cell biology for studying signalling between cells. For example, findings from this paper have been used by Fenwick et al. (Endocrinology, 2011, 152, 3515) to target the identification of bone-morphogenetic protein antagonists in the ovary.