Output details
13 - Electrical and Electronic Engineering, Metallurgy and Materials
University of Central Lancashire
Article title
The σ-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b
Type
D - Journal article
Title of journal
ChemMedChem
Article number
-
Volume number
7
Issue number
4
First page of article
722
ISSN of journal
18607179
Year of publication
2012
Number of additional authors
15
Additional information
This is one of the relatively few papers to recognise the importance of halogen bonding/σ-hole effect in drug design efforts, and was highlighted for this reason in the article “Principles and applications of halogen bonding in medicinal chemistry and chemical biology” by Wilcken R et al., J Med Chem 2013, 56(4), 1363-1388. With respect to glycogen phosphorylase inhibition, the unravelling of deficiencies in the pharmacokinetic profile of the glucose derivatives studied will influence researchers in the design of more effective ‘drug-like’ analogues.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
