Output details
11 - Computer Science and Informatics
University of Edinburgh
Article title
Internal coarse-graining of molecular systems
Type
D - Journal article
Title of journal
Proceedings of the National Academy of Sciences of the United States of America - PNAS
Article number
-
Volume number
106
Issue number
16
First page of article
6453
ISSN of journal
0027-8424
Year of publication
2009
Number of additional authors
4
Additional information
<28> Originality: This paper develops a novel, sound and automated method to construct coarse-grained dynamics of rule-based models.
Significance: Rule-based models provide a compact alternative to approaches that require explicit enumeration of all possible molecular species of a system of biomolecules. The method presented here does not require the execution of the rule-based model, is independent of model rate constants, and typically forms a system of greatly reduced dimension.
Rigour: The method is formal, which makes its properties more transparent and amenable to proof. Demonstrated on a substantial section of the EGFR pathway.
Interdisciplinary
Yes
Cross-referral requested
-
Research group
F - Laboratory for Foundations of Computer Science
Citation count
64
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
