Output details

Design criteria for a printed tissue engineering construct: A mathematical homogenization approach

Significance of output:

The market for cartilage repair is over 1 million patients per year in the US alone. However current therapies have severe limitations and are ineffective in the long term. This work is part of a wider research programme to develop ‘bio-printing’ approaches for tissue engineering, i.e. creating 3D constructs consisting of living cells to generate functionally competent cartilage replacements. The paper is the result of a multidisciplinary, international collaboration resulting in a rigorous multi-scale modelling approach to nutrient transport in bio-printed constructs. This is important for optimizing construct design and culture parameters to achieve successful tissue regeneration and scale up.