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15 - General Engineering

University of Glasgow

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Article title

Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells

Type

D - Journal article

DOI

10.1039/b902083g

Title of journal

Lab On a Chip

Article number

Volume number

Issue number

First page of article

2659

ISSN of journal

1473-0197

Year of publication

2009

URL

Number of additional authors

Additional information

The paper is the first description of microfluidic arrays of single, patient-derived cells to explore chronic myeloid leukaemia (CML), a hematopoietic stem cell disorder. Dynamic, on-chip, three-colour cell viability assays revealed information on the heterogeneity of response of cells to the first-line drug, dasatinib. This work was a major output of the IRC in Proteomic Technologies (BB/C511572/1) and has since informed clinical practice on the treatment of CML regarding the efficacy of the drug within the Leukaemia and Lymphoma Research and Therapy Acceleration Programme at the Beatson West of Scotland Cancer Centre (Contact: Dr. Copland, Mhairi.Copland@glasgow.ac.uk).

Interdisciplinary

Yes

Cross-referral requested

Research group

E - Biomedical Engineering

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract