Output details
15 - General Engineering
University of Southampton
Efficient self-assembly of DNA-functionalized fluorophores and gold nanoparticles with DNA functionalized silicon surfaces: the effect of oligomer spacers
Significance of output:
We demonstrate the first biomolecular assembly of DNA molecules to pattern gold nanoparticles on silicon, as needed for the fabrication of artificial life, nanoelectronic and bioplasmonic technology. A highly accurate determination of gold nanostructures and DNA hybridisation densities are achieved for the first time using a mass spectrometry approach, by adapting expertise of the National Oceanography Centre for elemental analysis of the ocean floor. This study, funded initially by the BBSRC (E16611 and E18926, £250K total), provided underpinning data for the BBSRC programme (BB/I023720/1 (2011-12) £117K) to pump-prime a novel plasmonic approach for DNA sequencing in collaboration with Renishaw Diagnostics.
