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12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering

University College London

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Output 8 of 200 in the submission

Article title

A methodology for global-sensitivity analysis of time-dependent outputs in systems biology modelling

Type

D - Journal article

DOI

10.1098/rsif.2011.0891

Title of journal

Journal of The Royal Society Interface

Article number

Volume number

Issue number

First page of article

2156

ISSN of journal

1742-5689

Year of publication

2012

URL

Number of additional authors

Additional information

This sophisticated methodology (only very recently published) will be key for exploring sensitivity and accuracy in complex physiological models to build towards use of complex quantitative phenomenological models in medicine. The method will be used to identify weaknesses that require more accurate data necessary if they are to be used in a clinical setting. The paper has inspired further work with clinical colleagues (in liver disease) identifying more accurate parameter values with a view to their use in diagnosis of liver disease.

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract