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The SMN Interactome Includes Myb-Binding Protein 1a

Reduced levels of SMN protein cause spinal muscular atrophy (SMA), the leading genetic killer of infants. SMN interacts with a large number of proteins, some of which contribute to SMN stability and may therefore be potential targets for SMA therapy. This study describes the characterisation of this “SMN interactome” and the identification of a novel SMN-binding partner, mybbp1a. Like SMN, mybbp1a was also reduced in cells from an SMA patient. In future, it may be possible to determine whether protein interactions identified in this study affect SMN stability and aid the design of SMA therapeutics aimed at increasing SMN protein.