Output details

Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency.

Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency. J Neurosci 33:12407-12422. This work, conducted at the Wellcome Trust/MRC Stem Cell Institute, detailed the potential for a population of human stem cells to differentiate into hindbrain neurons. The role of MA Gates was to: conduct the initial in vivo studies; train Dr. Jignesh Tailor (first author) to do such transplants; and to help identify the cellular population after transplantation. The work expanded the technical repertoire of Professor Smith’s group, and provided details on the potential of an established population of human neural stem cells to differentiate into mature neurons.