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Output details

11 - Computer Science and Informatics

Keele University

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Output title

Theory and practice of optimal mutation rate control in Hamming spaces of DNA sequences

Type

E - Conference contribution

DOI

10.7551/978-0-262-29714-1-ch017

Name of conference/published proceedings

Advances in Artificial Life, ECAL 2011: Proceedings of the Eleventh European Conference on the Synthesis and Simulation of Living Systems

Volume number

Issue number

First page of article

ISSN of proceedings

Year of publication

2011

URL

Number of additional authors

Additional information

<28>This paper generalizes Fisher's famous 1930's geometric phenotypic model of adaptation to a genetic model and derives probability of adaptation as a function of mutation rate, and optimal mutation rate functions for artificial landscapes. Further, these theoretical functions are evaluated against optimal mutation functions evolved using a meta-genetic algorithm. Experimental results verify the new theory, in both artificial landscapes and a natural landscape defined by DNA-transcription factor affinities. The work was undertaken within EPSRC project EP/H031936/1 and formed the essential theoretical underpinning to our recently awarded BBSRC grant (BB/L009579/1) which seeks to advance knowledge of how bacteria evolve antibiotic resistance.

Interdisciplinary

Yes

Cross-referral requested

Research group

B - Computational Intelligence and Cognitive Science

Citation count

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract