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13 - Electrical and Electronic Engineering, Metallurgy and Materials
University of Cambridge
A modified Drucker-Prager Cap model for die compaction simulation of pharmaceutical powders
Pharmaceutical tableting by die compaction is an industrially important process [Elliott and Hancock, MRS Bulletin 31(2006)869], with still around 70% of all pharmaceutical drugs consumed as solid oral dosage forms. However, the high cost of bringing new active compounds to market (>£1 billion) is impacted by the time-consuming formulation of powder blends suitable for compaction. The modelling methods developed here allow prediction of tablet behaviour from powder properties, significantly reducing development costs within Pfizer (contact: bruno.c.hancock@pfizer.com). This work formed part of invited review article on multiscale modelling [International Materials Review 56(2011)207].
