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12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering

University of Cambridge

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Article title

Azamacrocycle Activated Quantum Dot for Zinc Ion Detection

Type

D - Journal article

DOI

10.1021/ac801396y

Title of journal

ANAL CHEM

Article number

Volume number

Issue number

First page of article

8260

ISSN of journal

0003-2700

Year of publication

2008

URL

Number of additional authors

Additional information

This emerged from collaborative projects (EPSRC GR/T17007/01 and /BBSRC E19751) generating scorpion azamacrocycles as biorecognition ligands. It is highly cited demonstrating biorecognition ligand/semi-conducting nanoparticle interaction with photo generated electron-hole pairs and measurement of intracellular Zn2+ accumulation in the patients with Alzheimer’s. It links with our clinical study on drug-active contrast agents at Addenbrookes Hospital (Wellcome Trust ISSF internship), whereas particular interest for our Sydney collaborators (http://groups.chem.usyd.edu.au/todd/research-azamacrocycles.html) stems from their candidature as drugs for HIV and cancer. They are interested in the influence of azomacrocyle Zn2+ binding linked to apoptosis and we are interested in their potential as sensitive imaging agents.

Interdisciplinary

Yes

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract