You are in : Home » Results & submissions » Select UOA » 12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering » View submission: Imperial College London » Outputs » Detail

Output details

12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering

Imperial College London

Return to search Previous output Next output

Output 0 of 0 in the submission

Article title

A quantitative atlas of histone modification signatures from human cancer cells

Type

D - Journal article

DOI

10.1186/1756-8935-6-20

Title of journal

Epigenetics & Chromatin

Article number

ARTN 20

Volume number

Issue number

First page of article

ISSN of journal

1756-8935

Year of publication

2013

URL

Number of additional authors

Additional information

This article presents a holistic and proteomic characterisation of histone post-translational modifications (PTMs) across 24 cancer cell lines, which was referenced by Biome as ‘a helpful resource for the community to further analyse and classify cancer cells’ (http://www.biomedcentral.com/biome/cancer-mapped-an-atlas-of-histone-modifications-across-cancer-cell-lines/). The LC-MS/MS workflow utilised in this article for quantitatively profiling histone PTMs is being translated to identify therapeutic targets with Pfizer-Neusentis (Dr. Rachel Grimley; Epigenetics Exploratory Lead) and has resulted in a joint Pfizer-Neusentis and Institute for Chemical Biology (ICB)-funded PhD studentship award (http://www.icb-cdt.co.uk/research/projects/profiling-the-methylome-targets-of-histone-lysine-methyltransferases).

Interdisciplinary

Yes

Cross-referral requested

Research group

B - Chemical Engineering

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract