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Electrochemical detection of the binding of Bacillus anthracis protective antigen (PA) to the membrane receptor on macrophages through release of nitric oxide.

Using improved biocompatible microsensor arrays, in collaboration with DSTL, we demonstrated for the first time that binding of protective antigen from B. anthracis to cell surface receptor CMG-2 leads to activation of inducible nitric oxide synthase. The publication contributed to an invitation to Taiwan, funded by the RoC government, to deliver 4 research presentations and an 18-hour lecture course at Kaohsiung National University’s Department of Chemical Engineering. The work was also presented at an invited keynote talk at Sensors in Medicine 2013.