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Output details

15 - General Engineering

Imperial College London

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Article title

Acute and chronic exposure to shear stress have opposite effects on endothelial permeability to macromolecules.

Type
D - Journal article
Title of journal
American Journal of Physiology-Heart and Circulatory Physiology
Article number
-
Volume number
298
Issue number
6
First page of article
H1850
ISSN of journal
1522-1539
Year of publication
2010
URL
-
Number of additional authors
4
Additional information

This study showed that widely-used acute methods for shearing endothelial cells give results that are not relevant to the chronic shear occurring in vivo, and provided a novel explanation for the anti-atherosclerotic effect of NO. Funded by BBSRC (bb/d522711/1, £215k, PI: Weinberg), it involved an international collaboration with KCL and Louisville University. The high-throughput chronic methods have been adopted by other groups (e.g. Sheffield University); used in 3 further papers; and presented in an invited plenary at the 6th International Symposium on Biomechanics in Vascular Biology and Disease, Rotterdam, 2011. Follow-on funding has been obtained for two further PhD students.

Interdisciplinary
Yes
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-