Output details
15 - General Engineering
Imperial College London
Engineering of regulated stochastic cell fate determination
This is the first synthetic biology investigation of how stochasticity in gene networks defines differentiation in eukaryotes. Our biological engineering expertise, combined with mathematical prowess of our collaborators, gave an experimentally-verified model of how cell fate is determined. Early presentation of this work was invited for plenary talks at international synbio and UK yeast conferences (SB6.0, BYG2013) and helped secure a £1.5M grant to re-engineer the yeast genome (BB/K019791/1). The DNA materials developed for this paper are now used to teach undergraduate synthetic biology at MIT, leading to Dr Ellis being named an editor of the journal ACS Synthetic Biology.