Output details
26 - Sport and Exercise Sciences, Leisure and Tourism
University of Leeds
Article title
Store-operated Ca2+ Entry in Malignant Hyperthermia-susceptible Human Skeletal Muscle
Type
D - Journal article
Title of journal
Journal of Biological Chemistry
Article number
-
Volume number
285
Issue number
33
First page of article
25645
ISSN of journal
0021-9258
Year of publication
2010
URL
-
Number of additional authors
4
Additional information
Store operated Ca2+ entry (SOCE) was recently identified in rodent skeletal muscle and subsequent studies led to the suggestion that SOCE maintains contractile force during intensive exercise, particularly in aged muscle. However, SOCE had not been demonstrated in human muscle nor had its possible role in muscle pathology been investigated. Here we used human muscle biopsy samples to demonstrate (i) that the SOCE pathway is present in human muscle (ii) that the inherited disease ‘malignant hyperthermia’ leads to activation of this pathway and exacerbation of the condition. This work lead to an award from the European MH Group to 1st Author.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
