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15 - General Engineering

University of Bristol

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Article title

How to turn a genetic circuit into a synthetic tunable oscillator, or a bistable switch

Type

D - Journal article

DOI

10.1371/journal.pone.0008083

Title of journal

PLoS ONE

Article number

Volume number

Issue number

First page of article

e8083

ISSN of journal

1932-6203

Year of publication

2009

URL

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0008083

Number of additional authors

Additional information

Paper describes how tools of non-linear analysis can be used to understand and change dynamics of genes composing novel synthetic network published previously by the authors [di Bernardo-2]. Using simulation and continuation techniques, it is shown that network can be turned into tunable synthetic oscillator or bistable switch. Results provide guidelines to re-engineer network in vivo to tune its dynamics. Paper was included in Plos One Synthetic Biology Collection [tinyurl.com/gen-eng-3], and in RECOMB Regulatory Genomics and Systems Biology 2009 Collection [tinyurl.com/gen-eng-107].

Interdisciplinary

Cross-referral requested

Research group

B - Applied Nonlinear Mathematics

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract