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15 - General Engineering

Keele University

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Output 59 of 127 in the submission

Article title

High field magnetic resonance microscopy of the human hippocampus in Alzheimer's disease: Quantitative imaging and correlation with iron

Type

D - Journal article

DOI

10.1016/j.neuroimage.2011.08.019

Title of journal

NEUROIMAGE

Article number

Volume number

Issue number

First page of article

1249

ISSN of journal

1053-8119

Year of publication

2012

URL

http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000298210600047&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=65c2c6c1224a08d1a3198315ff59119e

Number of additional authors

Additional information

This paper represents the first step towards translating the studies we have conducted on mapping and characterizing brain iron associated with Alzheimer’s into an MRI diagnostic technique. In collaboration with the US National High Magnetic Field Laboratory, we present the first composite images of synchrotron x-ray mapped iron distribution and R2 MR images. We demonstrate a positive correlation between R2, R2* and iron biomineralization in AD tissue and show differences in the R2/R2* MR images between controls and AD in the Cornu Ammonis and dentate gyrus. This work was funded by NIH (5R01AG021030 & 1R21NS060304) and MRC (G0001009).

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract