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15 - General Engineering

Keele University

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Article title

Magnetic nanoparticle-mediated gene transfer to oligodendrocyte precursor cell transplant populations is enhanced by magnetofection strategies.

Type

D - Journal article

DOI

10.1021/nn2018717

Title of journal

ACS Nano

Article number

Volume number

Issue number

First page of article

6527

ISSN of journal

1936-086X

Year of publication

2011

URL

Number of additional authors

Additional information

The first demonstration that magnetic nanoparticles deployed with oscillating magnetofection technology enhance transfection in oligodendrocyte precursors [(OPs). We also demonstrated for the first time, that the protocols can deliver neurotherapeutic genes to OPs to support their regenerative potential. This work led to an EPSRC E-TERM Landscape fellowship for author Jenkins, held in the Chari laboratory (£200K, # R4504B276) for follow on studies, and won Best Abstract prize at a British Neuroscience Association meeting, Manchester, 2012. The fellowship involves collaboration with Keele spin-off company nanoTherics Ltd, to test a novel prototype magnetofection device (Contact CEO, Dr Carlton Jones, Tel: 01782 622112).

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract