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15 - General Engineering

King's College London

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Article title

Can perfusion CT assessment of primary colorectal adenocarcinoma blood flow at staging predict for subsequent metastatic disease? : A pilot study

Type

D - Journal article

DOI

10.1007/s00330-008-1128-1

Title of journal

European Radiology

Article number

Volume number

Issue number

First page of article

ISSN of journal

0938-7994

Year of publication

2009

URL

Number of additional authors

Additional information

Following on from Goh Radiology, 2008, this was the first study to demonstrate the potential of colorectal cancer blood flow measurement by perfusion CT as a prognostic biomarker: low flow tumours appear more likely to metastasize. This study led to successful NIHR funding in 2009 of a multi-centre clinical trial (PROSPeCT: CI - Goh, £1.3M) to assess generalisability within the NHS, using Perfusion CT to predict likelihood of metastasis and develop a prognostic model for colorectal cancer. This trial is enabling the technique to be embedded within the NHS at 22 sites, and to develop standardization & quality of practice.

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract