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The importance of structured noise in the generation of self-organizing tissue patterns through contact-mediated cell-cell signalling

This paper presents new evidence that biological cellular systems can use noise to induce order in a pattern-forming system. The multidisciplinary work has been reviewed in four biological journals including Development and was one of the ten most downloaded papers for Royal Society Interface journal in 2010. The work contributes to a wider understanding of scaling in biological structures, a theme the third author explored in his Royal Institution Christmas Lectures, which had a worldwide viewing audience of 8.5 million. In 2012 the patterning predictions of the paper were confirmed experimentally by Inaba et al. Science 2012: 335 (6069), 677.