Output details
15 - General Engineering
University College London
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Article title
The osteoinductivity of silicate-substituted calcium phosphate.
Type
D - Journal article
Title of journal
Journal of Bone and Joint Surgery: American Volume
Article number
-
Volume number
93
Issue number
23
First page of article
2219
ISSN of journal
1535-1386
Year of publication
2011
URL
-
Number of additional authors
5
Additional information
The work, in an ovine model, showed the use of a silicon containing bone graft substitute resulted in significantly increased amounts of bone (7-fold increase) within and in direct contact (12-fold increase) with the scaffold compared to non-silicon containing material. This work is of high importance as it too has led to the development of graft substitute materials developed with and marketed by Baxter Healthcare. This work showed the significant effect of adding silicate ions to the lattice of a hydroxyapatite scaffold. Silicate-substituted hydroxyapatite bone graft substitute materials are now used clinically and mainly in spinal fusion surgery.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
