Output details
15 - General Engineering
University College London
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Output 0 of 0 in the submission
Article title
Theoretical and experimental characterisation of magnetic microbubbles.
Type
D - Journal article
Title of journal
Ultrasound Med Biol
Article number
-
Volume number
38
Issue number
5
First page of article
864
ISSN of journal
1879-291X
Year of publication
2012
Number of additional authors
4
Additional information
This proof-of-concept report came from my idea to use magnetic microbubbles as transfection agents. The data were on the in vitro transfection of small molecules and of plasmid DNA, and showed an unprecedented five-fold improvement over the best-in-class laboratory transfection modalities currently available. Furthermore, the work opened up the hitherto-inaccessible prospect of in vivo drug and gene therapeutic delivery via blood-borne microbubbles actuated by external fields and activated by ultrasound. The team has subsequently validated this in vivo modality in a mouse model. This work was patented in 2011, and discussions have been initiated with Eli Lilley.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
