Output details
13 - Electrical and Electronic Engineering, Metallurgy and Materials
University of Birmingham : A - Electronic, Electrical and computer engineering
A constrained least-squares approach to the automated quantitation of in vivo (1)H magnetic resonance spectroscopy data.
Totally Automatic Robust Quantitation in NMR (TARQUIN) is a new, Birmingham developed method, for the fully automatic analysis of in vivo 1H Magnetic Resonance Spectroscopy. The novelty of the approach reported, compared to other methods, is that all analyses are performed in the time-domain and it applies soft constraints to signal amplitudes in order to improve measurement accuracy. Instead of using experimental basis sets for spectral fitting, we uniquely calculate metabolite components by a universal quantum simulator, avoiding dependence on continuous collection of instrument-based calibration measurements. TARQUIN is open source software and has been supported by MRC and CRUK funding.
