Output details
12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
Imperial College London
A mathematical modelling framework for understanding chemorepulsive signal transduction in Dictyostelium.
This is the first modelling paper (Pubmed) on chemorepulsion (migration away from chemicals), a process involved in tumour cell spreading, angiogenesis (blood-network formation), immune transplant rejection. It employs a multi-model approach to elucidate chemorepulsion in a model organism. This resulted in the development of a new cell-type-independent systems-design methodology to understand how cells are wired to exhibit both chemorepulsion and chemoattraction (JTB:273:80-99:2011) for controlling migration in a variety of cell types, keynote lectures (ActinCellPolarity, Warwick, 2008, Angionet2009, Dundee), invited lectures (Oxford 2011), systems biology talks (ICSB2013, Copenhagen), emerging collaborations (Prof.Eickholt:Britta.Eikholt@charite.de) applying results to neurons, and conference prizes (ChemEngDayUK, 2013).
