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3-D ultrasonic strain imaging using freehand scanning and a mechanically-swept probe-correspondence

The techniques described in this paper were used for intra-operative neurosurgery studies at the Royal Free Hospital in London (Christopher Uff, Department of Neurosurgery, Royal Free Hospital, London, ID_in_audit_file@hotmail.com). They demonstrated, for the first time, approximately real-time 3-dimensional elastograms showing the structure of brain tumours (Uff et al, Proc. 2009 IEEE International Ultrasonics Symposium, 467-470). The potential impact is more complete tumour resection: Uff's PhD thesis (University of London, 2011) found a statistically significant improvement for tumour boundary characterization with 3D elastography as compared to 2D. The first author went on to a research position at King's College London.