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13 - Electrical and Electronic Engineering, Metallurgy and Materials

University of Ulster

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Article title

Modelling of shear stress experienced by endothelial cells cultured on microstructured polymer substrates in a parallel plate flow chamber.

Type

D - Journal article

DOI

10.1002/bit.23022

Title of journal

Biotechnology and bioengineering

Article number

Volume number

108

Issue number

First page of article

1148

ISSN of journal

1097-0290

Year of publication

2011

URL

Number of additional authors

Additional information

Originating under EPSRC IMRC "MATCH" (EP/F063822/1) and supported by National Access Programme (Science Foundation Ireland, NAP-149), this paper highlights the advantages of integrating computational fluid dynamics, in-vitro culture and distinct multiple physical stimuli in the study of shear stress at sub-cellular scale lengths and its effect on endothelial cells. We showed conclusively that aligned cells experienced significantly lower spatial shear stress gradients compared to non-aligned cells. It was awarded the prize for best use of microscopy at UKSB 2009 and the author was invited to present this work at the University of Louisville (eric.berson@louisville.edu) in 2011.

Interdisciplinary

Cross-referral requested

Research group

A - Biomaterials

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract