Output details
15 - General Engineering
Keele University
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Article title
The SMN Interactome Includes Myb-Binding Protein 1a
Type
D - Journal article
Title of journal
Journal of Proteome Research
Article number
-
Volume number
9
Issue number
1
First page of article
556
ISSN of journal
1535-3907
Year of publication
2010
URL
-
Number of additional authors
-
Additional information
Reduced levels of SMN protein cause spinal muscular atrophy (SMA), the leading genetic killer of infants. SMN interacts with a large number of proteins, some of which contribute to SMN stability and may therefore be potential targets for SMA therapy. This study describes the characterisation of this “SMN interactome” and the identification of a novel SMN-binding partner, mybbp1a. Like SMN, mybbp1a was also reduced in cells from an SMA patient. In future, it may be possible to determine whether protein interactions identified in this study affect SMN stability and aid the design of SMA therapeutics aimed at increasing SMN protein.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-