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15 - General Engineering

Keele University

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Output 44 of 127 in the submission

Article title

Delivery of short interfering ribonucleic acid-complexed magnetic nanoparticles in an oscillating field occurs via caveolae-mediated endocytosis.

Type

D - Journal article

DOI

10.1371/journal.pone.0051350

Title of journal

PLoS One

Article number

Volume number

Issue number

First page of article

e51350

ISSN of journal

1932-6203

Year of publication

2012

URL

http://www.ncbi.nlm.nih.gov/pubmed/23236481

Number of additional authors

Additional information

Nanomagnetic gene transfection was first demonstrated by our group at the University of Florida in 1999. This paper is the first to elucidate mechanisms by which particle/DNA complexes are internalized in oscillating and static nanomagnetic gene transfection. The oscillating technique has several advantages over other non-viral transfection methods, including rapid transfection time, high cell viability, and enhanced gene expression and transfection efficiency. I hold two patents on this technology (with others pending) and it forms the basis of a successful spin-off company, nanoTherics (www.nanotherics.com). This work was funded by CFGT Consortium, MRC Milstein Award (G0701054), BBSRC (BB/C506172).

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract