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13 - Electrical and Electronic Engineering, Metallurgy and Materials

University of Southampton

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Article title

Microfluidic array platform for simultaneous lipid bilayer membrane formation

Type

D - Journal article

DOI

10.1016/j.bios.2008.07.022

Title of journal

Biosensors and Bioelectronics

Article number

Volume number

Issue number

First page of article

1235

ISSN of journal

0956-5663

Year of publication

2009

URL

http://www.eprints.soton.ac.uk/270657

Number of additional authors

Additional information

Significance of output:

The systematic screening of ion channel-targets is important in drug discovery. This paper describes a multiplexed ion-channel recording technology for the analysis of drugs using artificial cell membranes. The paper led to further EPSRC funding (EP/H044795/1 £860,000) to enable a project with molecular biologists at Birkbeck College. Our new technology integrates custom designed low-noise ASICs with a disposable microfluidic platform to screen sodium channel activity, specifically for drugs to target pain. The technology platform is in the process of being licenced and sold through Warner Instruments, USA (confidential). This paper has featured widely in critical reviews of this new field.

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract