Output details
12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
University of Cambridge
Extrusion-spheronisation of highly loaded 5-ASA multiparticulate dosage forms.
This research, which was in collaboration with the University of Milan (contact available on request), lays a pathway for revolutionising the development of tablets containing a relatively high dose of active pharmaceutical ingredient, with the intention of decreasing the number of tablets consumed daily by patients. The study is the first to provide a solution to the processing problems associated with these high dosage formulations. The success of the work led to further collaboration with the University of Milan, and another publication on the optimisation and scale-up of high dosage forms (Eur. J. Pharm. Sci., 45, 158-168, 2012).