Output details
11 - Computer Science and Informatics
University of Hertfordshire
Article title
Analysis of context-dependent errors for Illumina sequencing
Type
D - Journal article
Title of journal
Journal of Bioinformatics and Computational Biology
Article number
1241005
Volume number
10
Issue number
2
First page of article
-
ISSN of journal
0219-7200
Year of publication
2012
URL
-
Number of additional authors
10
Additional information
<28> In Next Generation Sequencing technology it is important to distinguish putative natural variants (SNPs) from sequencing- or other errors. This study shows that the detection of SNPs (“SNP calling”) is affected by the identity of surrounding nucleotides. Around 80% of false positive SNPs can be corrected with the “second best call" probability, conditional on that of the first call. The study was carried out in collaboration with the Wellcome Trust Sanger Institute in Hinxton (Cambridge), a world leader in the field of DNA sequencing.
Interdisciplinary
Yes
Cross-referral requested
-
Research group
None
Citation count
2
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
