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A Practical Approach for Using Solubility to Design Cooling Crystallisations

Crystallisation is the single most important method of isolating agrochemical and pharmaceutical active ingredients. This work significantly reduced the development resource required to develop a robust industrial manufacturing process. Re-analysing 105 solubility datasets demonstrated that solubility, on average, doubles every 20C. This simple observation had a huge impact on how chemists and engineers approach crystallisation processes as it justified solvent screening at 20C, simple and quick, as an alternative to experimentalist’s solvent preferences. The work provides an algorithm for crystallisation development, now embedded across all AstraZeneca (simon.black@astrazeneca.com) and already used to develop more than 50 new potential drug compounds.