Output details
11 - Computer Science and Informatics
University of Manchester
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Article title
Array-based evolution of DNA aptamers allows modeling of an explicit sequence-fitness landscape
Type
D - Journal article
Title of journal
Nucleic Acids Research
Article number
e6
Volume number
37
Issue number
1
First page of article
-
ISSN of journal
1362-4962
Year of publication
2009
URL
-
Number of additional authors
8
Additional information
<28> The concept of a fitness landscape is central to understanding how evolution works in detail, and to an understanding of evolutionary dynamics. This paper is significant because it pioneers a new method for exploring real DNA fitness landscapes: the system "evolves" a population of DNA strands by synthesising them on a microarray platform, measures their binding to a target, and sends the information to a computer, which then instructs the microarray platform about which DNA strands to make next. Machine learning techniques are used to predict the properties of unseen DNA strands to a high level of accuracy.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Citation count
18
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
