Output details

Flexible structural protein alignment by a sequence of local transformations

<24>Research spans computer science and bioinformatics. Method based on structural pattern recognition approach developed at York. Demonstrates the need for flexible geometry in protein matching. Evaluated against 9 state-of-the-art methods on 3 standard databases. One of the first papers proposing a flexible alignment approach (effectiveness later verified in "Protein Structure Alignment: Is There Room for Improvement?", Arriagada and Poleksic, 2012). Resulted from collaboration with partners of EU INTAS project on protein structure matching with Moscow State University, BRIEM and UIIP Minsk, and University of Balearic Islands. Led to the development of a publicly available server for 3D protein comparison http://dmi.uib.es/ProtDeform/