Output details

Homologous recombination restarts blocked replication forks at the expense of genome rearrangements by template exchange

(a) I made a substantial contribution to the conception and design of the study, to carrying out the study (including acquisition of study data) and to analysis and interpretation of study data. Experiments that first identified acentric and dicentric chromosomes as a product of homologous recombination dependent restart were carried out in my lab and led to a radical change in concept and design. In addition, analysis which showed that Rqh1(BLM) limits Rad51-dependent template exchange at blocked replication forks was carried out as part of my BBSRC grant (BB/C510291/1) which funded Dr Ken’Ichi Mizuno (second author) in my lab.

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(b) I helped draft the output and critique the output for important intellectual content.