Output details
15 - General Engineering
University of Edinburgh (joint submission with Heriot-Watt University)
A versatile CARS microscope for biological imaging
The innovative development of a hybrid CARS-AFM microscope is reported, together with its capability to provide the first 3-D topographical images of cancerous breast tissue at 10 nm resolution. Further validation of the microscope’s potential importance to biomedical research includes applications to cancer (DoI:10.1002/jrs.2622), stem cells (DoI:10.1117/1.JBO.17.11.116011) and neurodegenerative diseases (DoI:10.1117/12.889772). This microscope can be hybridised with other non-invasive imagining modes, and this was highlighted in “Annual Review of Analytical Chemistry” (DoI:10.1146/annurev-anchem-062011-143152). Through CRUK funding (C157/A12753, £250k, with Downes as co-I) a dedicated facility for this instrument now exists at the Edinburgh Cancer Research UK Centre.