Output details
15 - General Engineering
Heriot-Watt University (joint submission with University of Edinburgh)
Label-free detection of amyloid growth with microcantilever sensors
Protein aggregation has critical clinical importance because it is associated with the intrinsic causes of many incurable diseases including Parkinson's and Alzheimer 's. Following related work published in PNAS (DOI: 10.1073/pnas.0610659104) in 2011 using a single Quartz Crystal Microbalance biosensor, this paper demonstrated for the first time that low-cost arrays of microcantilever sensors can be used for real time detection of protein aggregation. This has significantly expanded the throughput of this type of measurement and are considered as a novel drug screening platform for relevant diseases by a review paper (DOI:10.1517/17460440903386643, Expert Opinion on Drug Discovery).
