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Output details

15 - General Engineering

Imperial College London

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Output 3 of 109 in the submission

Article title

A device to study the effects of stretch gradients on cell behavior.

Type

D - Journal article

DOI

10.1115/1.4005251

Title of journal

Journal of Biomechanical Engineering-Transactions of the Asme

Article number

Volume number

133

Issue number

First page of article

101008

ISSN of journal

1528-8951

Year of publication

2011

URL

Number of additional authors

Additional information

Awarded the ASME Bioengineering Division Richard Skalak Best Paper Award. This is the first device to subject cultured cells to physiologic mechanical stress gradients and quantify their behaviour. Previous devices only apply uniform stretch. Allows for quantification of cell behaviours in real time that are important in several disease conditions. Collaboration with cell physiology group at Texas A&M Medical School. A USA group adapted the technique for their lab (Balestrini et al., Biomech Model Mechanbiol, 9: 329-44). IP disclosed to Texas A&M. Two additional publications and one invited talk have resulted.

Interdisciplinary

Yes

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract