Output details
11 - Computer Science and Informatics
University of East Anglia
Article title
Path of nascent polypeptide in exit tunnel revealed by molecular dynamics simulation of ribosome
Type
D - Journal article
Title of journal
Biophysical Journal
Article number
-
Volume number
95
Issue number
12
First page of article
5962
ISSN of journal
00063495
Year of publication
2008
URL
-
Number of additional authors
1
Additional information
<28> The work reported here began in 2006 when Hayward visited the Japan Atomic Energy Agency. It presents results of one of the largest Molecular Dynamics simulations performed at that time with 1.9 million atoms simulated. The aim was to determine the path taken by the nascent polypeptide in the exit tunnel of a bacterial ribosome, a target region for antibiotics. Results suggest that amino-acid Arg92 acts as a gate opening and closing the tunnel. The work was supported by a JST Strategic Japan-U.K. Cooperative Program grant awarded to Ishida and Matsumoto with Hayward supported by the BBSRC.
Interdisciplinary
Yes
Cross-referral requested
-
Research group
None
Citation count
14
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
