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Output details

15 - General Engineering

University of Bristol

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Output 364 of 446 in the submission

Article title

Rhythmic actomyosin-driven contractions induced by sperm entry predict mammalian embryo viability

Type

D - Journal article

DOI

10.1038/ncomms1424

Title of journal

Nature Communications

Article number

417

Volume number

Issue number

First page of article

ISSN of journal

2041-1723

Year of publication

2011

URL

http://www.nature.com/ncomms/journal/v2/n8/full/ncomms1424.html

Number of additional authors

Additional information

Paper pioneers non-invasive way of assessing likelihood of embryo development. Natural motion of egg cytoplasm is shown to correlate with calcium activity, which synchronises events within cell. Motion is captured using cross-correlation-type algorithms, and statistical model developed to predict cell viability. Validation was carried out using direct (toxic) calcium markers and by measuring birth success after implantation into the mother.

Technique has been patented (US 61/503827) and licensed commercially for development in human clinical setting after follow-on work by Windsor suggests similar correlations in humans [contact: IP Rights Officer, University of Oxford].

Interdisciplinary

Cross-referral requested

Research group

I - Robotics

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract