Output details

Coupled modeling of blood perfusion in intravascular, interstitial spaces in tumor microvasculature

This output stemmed from collaboration with Fudan University, China and the Mount Vernon Cancer Centre. Tumour microcirculation is characterised by increased vessel leakiness in human cancer. This feature was incorporated into a mathematical model of tumour angiogenesis by coupling the intravascular and interstitial flow point belonging to either the connected vessel or interstitial space by vascular leaky terms. Vessel compliance and blood rheology with branch hematocritic distribution were also considered. Vascular leakiness is key to govern the systemic flowing pattern, influence the tumour internal environment and contribute to the metastasis of tumour cells. The results agreed with reported experimental observations.